Pritam Thapa Selected Research

Type I DNA Topoisomerases (Topoisomerase I)

9/2014	Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.
6/2012	Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety.
3/2012	Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
2/2012	2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
8/2011	Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
5/2010	Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines.
3/2010	Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
1/2010	2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
1/2010	2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.
7/2007	2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

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Pritam Thapa Research Topics

Disease

19	Neoplasms (Cancer) 01/2022 - 07/2007
2	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2021
2	Breast Neoplasms (Breast Cancer) 01/2016 - 02/2015
1	Phototoxic Dermatitis (Phototoxicity) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Communicable Diseases (Infectious Diseases) 01/2021
1	Chronic Disease (Chronic Diseases) 10/2020
1	Ovarian Neoplasms (Ovarian Cancer) 04/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2016
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 04/2013
1	Multiple Myeloma 04/2013
1	Stroke (Strokes) 08/2011
1	Idiopathic Pulmonary Fibrosis 08/2011

Drug/Important Bio-Agent (IBA)

10	Type I DNA Topoisomerases (Topoisomerase I)IBA 09/2014 - 07/2007
5	ProdrugsIBA 01/2022 - 04/2016
5	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 01/2010
5	pyridineIBA 01/2016 - 01/2010
4	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2022 - 04/2016
4	PyridinesIBA 01/2016 - 05/2010
3	Singlet OxygenIBA 12/2017 - 04/2016
3	Photosensitizing Agents (Photosensitizers)IBA 12/2017 - 04/2016
3	Paclitaxel (Taxol)FDA LinkGeneric 12/2017 - 04/2016
2	Biological ProductsIBA 01/2021 - 10/2020
2	Pharmaceutical PreparationsIBA 04/2016 - 04/2013
2	trioctyl phosphine oxide (TOPO)IBA 01/2016 - 07/2015
2	Etoposide (VP 16)FDA LinkGeneric 10/2015 - 02/2015
2	Hydroxyl RadicalIBA 07/2015 - 05/2010
1	Donepezil (Aricept)FDA LinkGeneric 01/2022
1	5-aminolevulinic acid hexyl ester FDA Link 01/2022
1	protoporphyrin IXIBA 01/2022
1	Chalcone (Benzalacetophenone)IBA 01/2021
1	Folic Acid (Vitamin M)FDA LinkGeneric 10/2017
1	Topoisomerase II InhibitorsIBA 10/2015
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2015
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 10/2015
1	DNA (Deoxyribonucleic Acid)IBA 02/2015
1	RetinoidsIBA 01/2014
1	Proteasome InhibitorsIBA 04/2013
1	BoronIBA 04/2013
1	Bortezomib (Velcade)FDA Link 04/2013
1	ElementsIBA 04/2013
1	quinolineIBA 02/2012
1	NADPH Oxidases (NAD(P)H oxidase)IBA 08/2011
1	pyrazolopyridineIBA 08/2011

Therapy/Procedure

3	Photochemotherapy (Photodynamic Therapy) 12/2017 - 04/2016
1	Drug Therapy (Chemotherapy) 04/2016